AM50469PU-N Brm antibody

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Rat anti Mouse Brm 1H7A10

Product Description for Brm

Rat anti Mouse Brm 1H7A10.
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Brm

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms ATP-dependent helicase SMARCA2, BRG1-associated factor 190B, Protein brahma homolog, SNF2/SWI2-like protein 2, SWI/SNF related, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2, actin dependent regulator of chromatin, global transcription activator homologous sequence, matrix associated, member 2, probable global transcription activator SNF2L2, subfamily a, sucrose nonfermenting 2-like protein 2
Presentation Purified
Reactivity Ms
Applications C, WB
Clonality Monoclonal
Clone 1H7A10
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Recombinant protein corresponding to amino acids 48-214 of mouse Brm.
Isotype control SM15P, SM15PX
Application Immunohistochemistry.
Western Blot: 0.5 µg/mL of this antibody detected Brm on 10 µg of K562 nuclear extract.
Background BAF190B (BRG1-associated factor 190B), also known as protein brahma homolog (Brm), and SNF2-alpha, functions as a transcriptional coactivator. This protein contains a helicase domain and is a member of the SWI/SNF family of proteins and is part of the SWI-SNF chromatin remodeling complex. The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. This large complex contains multiple proteins. BAF190 (Brm) and Brg-1 (SNF2-beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, or SNF5), BAF155 (SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
Concentration lot-specific
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Protein G Chromatography
Buffer System:
0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Liquid purified Ig fraction
Recognizes BAF190B also known as Brm
Demonstrated to react with human and mouse.

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