TA306410 BRSK1 (C-term) antibody

Rabbit Polyclonal BRSK1 Antibody

See related secondary antibodies

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0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat BRSK1

TA306410

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  • TA306410

Product Description for BRSK1

Rabbit anti Human, Mouse, Rat BRSK1.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for BRSK1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms BR serine/threonine-protein kinase 1, KIAA1811, SAD-B, SAD1, SAD1 kinase, Serine/threonine kinase SAD-B
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8TDC3
Immunogen:
BRSK1 antibody was raised against a 28 amino acid peptide from near the carboxy terminus of human BRSK1. (AP30166CP-N)
GeneID:
84446
Property C-term
Add. information Blocking peptide available: blocking peptide (AP30166CP-N)
Application ELISA.
Western Blot: BRSK1 antibody can be used for detection of BRSK1 at 0.5 – 1 μg/ml.
Immunohistochemistry.
Background BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
General Readings
  1. Lu R, Niida H, Nakanishi M. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J Biol Chem. 2004 Jul 23;279(30):31164-70. Epub 2004 May 18. PubMed PMID: 15150265.
  2. Kishi M, Pan YA, Crump JG, Sanes JR. Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11;307(5711):929-32. PubMed PMID: 15705853.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody reacts to BRSK1.
Species:
Human, Mouse, Rat.

Accessory Products

Proteins and/or Positive Controls

Proteins for BRSK1 (4 products)

Catalog No. Species Pres. Purity   Source  

BRSK1

BRSK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BRSK1

BRSK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

BRSK1

BRSK1 Human
  Abnova Taiwan Corp.

BRSK1

BRSK1 Human
  Abnova Taiwan Corp.

Positive controls for BRSK1 (1 products)

Catalog No. Species Pres. Purity   Source  

BRSK1 overexpression lysate

BRSK1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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