NB120-4717 c-Abl antibody

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Rabbit anti Human c-Abl


Product Description for c-Abl

Rabbit anti Human c-Abl.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for c-Abl

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human c-Abl 1b that contains tyrosine 412. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, designated 1b (the more common form) and 1a. The corresponding phosphorylation site from 1a is tyrosine 393.
Background c-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor (PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein Bcr/Abl. c-Abl becomes fully activated by sequential phosphorylation of tyrosines 412 and 245.
General Readings General / background references:Cong F et al. Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase. J Biol Chem 277:34870-8 (2002). PubMed PMID: 12107171
Furstoss O et al. c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J 21:514-24 (2002). PubMed PMID: 11847100
Brasher BB & Van Etten RA c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines. J Biol Chem 275:35631-7 (2000). PubMed PMID: 10964922
Plattner R et al. c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev 13:2400-11 (1999). PubMed PMID: 10500097
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium AzideConstituents: PBS (without Mg2+ and Ca2+), 1.0mg/ml BSA (IgG, protea
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen) due to sequence homology.Not yet tested in other species.

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