NB120-2995 c-erb B 4 antibody

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0.5 ml / €420.00

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Rabbit anti Human, Mouse, Rat c-erb B 4


Product Description for c-erb B 4

Rabbit anti Human, Mouse, Rat c-erb B 4.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for c-erb B 4

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide (amino acids 1285 - 1308) from the C terminus of human c-erb B 4 / HER 4 oncoprotein.
Background c-erb B 4 is the fourth member of class I receptor kinase family (ErbB). HER 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumour cell lines T47 D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF 7, MDA-MB-330 and MDA-MB-361. Expression of erb B 4 is low or absent in some breast tumour cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, andSKBR-3.
General Readings General / background references:Tang CK et al. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Cancer Res 59:5315-22 (1999). PubMed PMID: 10537315
Chen X et al. An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. J Biol Chem 271:7620-9 (1996). PubMed PMID: 8631797
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein A purified
Cross-reacts with Human, Rat and Mouse.Not yet tested in other species.

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