discontinued

AM33126SU-S CA 19-9 antibody

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Search for all "CA 19-9"

0.1 ml / €150.00

Quick Overview

Mouse anti Human CA 19-9 121SLE

Product Description for CA 19-9

Mouse anti Human CA 19-9 121SLE.
Presentation: Supernatant
Product is tested for Western blot / Immunoblot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Frozen Sections, Paraffin Sections.

Properties for CA 19-9

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms CA19-9, Sialosyl Lewis a, Sialyl Lewis a
Presentation Supernatant
Reactivity Hu
Applications C, F, ICC/IF, P, WB
Clonality Monoclonal
Clone 121SLE
Host Mouse
Isotype IgM
Molecular weight > 400kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Immunoprecipitate obtained after immunodiffusion of MAb 19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le).
Application Western Blot: 1/100-1/200.
Flow Cytometry:
5-10 µl/106 cells.
Immunofluorescence:
1/25-1/50.
Immunohistochemistry on Frozen and Formalin-Fixed
 Paraffin Sections: 1/50-1/100 for 30 minutes at RT. 
No special pretreatment is required for the immunohistochemical staining of formalin-fixed, paraffin-embedded tissues. 
Positive Control: Stomach.
Background CA19-9, a carbohydrate epitope expressed on a high MW (> 400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewisa and/or Lewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings.
General Readings
  1. Rouger Ph. et al. (Eds.): Proceedings of the First International Workshop on monoclonal antibodies against human red blood cells and related antigens (Paris, 1987) published in: Blood Transfusion and Immunohaematology 30 (5), pp 353-720.
  2. Rye PD, Bovin NV, Vlasova EV, Molodyk AA, Baryshnikov A, Kreutz FT, et al. Summary report on the ISOBM TD-6 workshop: analysis of 20 monoclonal antibodies against Sialyl Lewisa and related antigens. Montreux, Switzerland, September 19-24, 1997. Tumour Biol. 1998;19(5):390-420. PubMed PMID: 9701730.
  3. Nomoto S, Nakao A, Ichihara T, Takagi H. Intraoperative quick immunoperoxidase staining: a useful adjunct to routine pathological diagnosis in pancreatic carcinoma. Hepatogastroenterology. 1995 Sep-Oct;42(5):717-23. PubMed PMID: 8751240.
  4. Webb A; Scott-Mackie P; Cunningham D; Norman A; Andreyev J; O'Brien M; Bensted J. European Journal of Cancer, 1996 Jan, 32A(1):63-8.
  5. Tsuruta T, Ogawa A, Ishii K, Ikado S. CA19-9: a possible serum marker for embryonal carcinoma. Urol Int. 1997;58(1):20-4. PubMed PMID: 9058515.
  6. van den Bosch RP, van Eijck CH, Mulder PG, Jeekel J. Serum CA19-9 determination in the management of pancreatic cancer. Hepatogastroenterology. 1996 May-Jun;43(9):710-3. PubMed PMID: 8799418.
  7. Kodera Y, Yamamura Y, Torii A, Uesaka K, Hirai T, Yasui K, et al. The prognostic value of preoperative serum levels of CEA and CA19-9 in patients with gastric cancer. Am J Gastroenterol. 1996 Jan;91(1):49-53. PubMed PMID: 8561143.
  8. Furuya N, Kawa S, Hasebe O, Tokoo M, Mukawa K, Maejima S, et al. Comparative study of CA242 and CA19-9 in chronic pancreatitis. Br J Cancer. 1996 Feb;73(3):372-6. PubMed PMID: 8562344. (Free PMC Article available)
  9. Wang FM, Tsai LC, Chang ZN, Han SH, Tsao D. The significance of CA19-9 tumor antigen in the serum of patients with carcinomas. Proc Natl Sci Counc Repub China B. 1985 Apr;9(2):119-25. PubMed PMID: 3863154.
  10. Nordén R, Nyström K, Aurelius J, Brisslert M, Olofsson S. Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T-cells: involvement of host and viral factors. Glycobiology. 2013 Mar;23(3):310-21. doi: 10.1093/glycob/cws160. Epub 2012 Nov 9. PubMed PMID: 23144050.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Preservatives:
0.05% Sodium Azide
State:
Liquid Bioreactor Concentrate
Supernatant
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
This 121SLE antibody is specific to CA19-9, which can predict recurrence of disease prior to radiographic treatment.

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