NB100-94204 CAD antibody

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Rabbit anti Mouse, Rat CAD

Product Description for CAD

Rabbit anti Mouse, Rat CAD.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for CAD

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rabbit anti-CAD (I17) polyclonal antibody was raised against a peptide corresponding to amino acids 205 to 222 of murine CAD (1).
Application Western Blot, This polyclonal antibody can be used for detection of CAD by Western blot at 1:500 to 1:1000 dilution. Murine kidney tissue lysate can be used as positive control and a 40 kDa band should be detected. It is mouse and rat reactive., Western Blot 1:500-1:1000,
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease) (1,2). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40 (3,4). Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively (5). Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei (1-4). Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
0.02% Sodium Azide
IgG purified
Mouse, Rat

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