discontinued

NB200-627 CaMK II pThr286 antibody

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0.05 ml / €340.00

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Rabbit anti Human, Mouse, Rat CaMK II

NB200-627

Product Description for CaMK II

Rabbit anti Human, Mouse, Rat CaMK II.
Properties: pThr286
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for CaMK II

Product Category Primary Antibodies
Quantity 0.05 ml
Synonyms Thr286
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr286 found in rat brain CaM Kinase II. Identical to human, mouse and Xenopus sequences over these residues.
Property pThr286
Background Calcium/calmodulin kinase II (CaM Kinase II, CaMKII) is a multi-functional calcium and calmodulin-dependent serine/threonine protein kinase that mediates cellular responses to second messengers. Phosphorylation of Thr286 produces an autonomously active form of CaM Kinase II. CaMKII is an enzyme which is activated by increases in intracellular Ca2+ ion con-centration and it has been proposed to be pivotal in regulating synaptic strength and maturation of synapses during development (5). This process is thought to be critical in memory and learning and in establishing the specificity of synaptic connections. There are over two dozen alternative splice variants of CaMKII which are encoded by four genes, a, b, g, and d with apparent molecular masses of 50-60 kDa (2). CaMKII is widely distributed in many tissues, but is highly expressed in brain (3). Several studies demonstrate that CaMKII is a multifunctional enzyme which modulates the synaptic strength by binding to a subunit of NMDA receptors and promoting the phosphorylation of this NMDA receptor subunit (4). CaMKII also regulates DLG localization at synapses by co-localization with DLG in the same protein complex (4).
General Readings
  1. Kennedy, M. B. (2000) Science 290: 750-754.
  2. Hardie, G. and Hanks, S. (1995) The Protein Kinase Facts Book, Protein-Serine Kinases Academic Press Limited, San Diego, CA 418p
  3. Kennedy, M.B. and Erondu, N.E. (1985) J. Neurosci. 5: 3270-3277.
  4. Gardoni, F. Schrama, L.H., Van Dalen, J.J., Gispen, W.H., Cattabeni, F. and Di Luca, M. (1999) FEBS Lett. 456: 394-398.
  5. Rongo, C. and Kaplan, J.M. (1999) Nature 402: 195-199.
Format
Purification:
Affinity purified
Buffer System:
10 mM HEPES, pH 7.5, 150 mM NaCl, 100ug/ml BSA and 50% glycerol
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Species:
Cross-reacts with Mouse, Rat, Human and Xenopus laevis.

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