discontinued

NB120-32678 CaMKII antibody

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0.1 mg / €390.00

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Rabbit anti Bovine, Canine, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep CaMKII

NB120-32678

Product Description for CaMKII

Rabbit anti Bovine, Canine, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep CaMKII.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for CaMKII

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CaMK II, CaMK2, CaMKII, Calmodulin-Dependent Protein Kinase II
Presentation Aff - Purified
Reactivity Bov, Can, Hu, Mky, Ms, Por, Rb, Rt, Sh
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Human CaMII phosphorylated synthetic peptide, corresponding to amino acids 281-288 and conjugated to KLH. This sequence differs from CaMKII beta by one residue.
Application immunoprecipitation, Western Blot, immunoprecipitation 12.5 ug/ml, Western Blot 2 ug/ml
Background CaMKII (Calcium/calmodulin-dependent protein kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma, and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits. CaMKII is a prominent kinase in the central nervous system that may function in long term potentiation and neurotransmitter release.
Concentration 1 mg/ml
General Readings
  1. Kennedy, M. B. (2000) Science 290: 750-754.
  2. Hardie, G. and Hanks, S. (1995) The Protein Kinase Facts Book, Protein-Serine Kinases Academic Press Limited, San Diego, CA 418p
  3. Kennedy, M.B. and Erondu, N.E. (1985) J. Neurosci. 5: 3270-3277.
  4. Gardoni, F. Schrama, L.H., Van Dalen, J.J., Gispen, W.H., Cattabeni, F. and Di Luca, M. (1999) FEBS Lett. 456: 394-398.
  5. Rongo, C. and Kaplan, J.M. (1999) Nature 402: 195-199.
Storage Store at -20C. Avoid freeze-thaw cycles.
Format
Purification:
Immunogen affinity purified
Buffer System:
No Preservative
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
This detects ~50 and ~60 kDa proteins, corresponding to the apparent molecular masses of phosphorylated CaM Kinase II a and b phosphorylated at Thr286 on SDS-PAGE immunoblots. This is specific for phosphorylated CaM Kinase II (Thr286) and does not exhibit reactivity with non-phosphorylated CaM Kinase II.
Species:
Bovine, Canine, Hamster, Human, Mouse, Porcine, Primate, Rabbit, Rat, Sheep

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