discontinued

NB120-832 cAMP (cyclic AMP) antibody

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0.1 ml / €360.00

Quick Overview

Sheep anti cAMP (cyclic AMP)

NB120-832

Product Description for cAMP (cyclic AMP)

Sheep anti cAMP (cyclic AMP).
Presentation: Serum
Product is tested for Enzyme Immunoassay, Radioimmunoassay.

Properties for cAMP (cyclic AMP)

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Applications E, R
Clonality Polyclonal
Host Sheep
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Succinylated cAMP conjugated to bovine serum albumin.
Application ELISA, This antibody may be used in radioimmunoassays to detect and quantitate cAMP; 50% binding is achieved with a 1:1,000 dilution. All this antibody may also be used in ELISA and to affinity purify cAMP. , ELISA , Radioimmunoassay 1:1,000
Background Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery. nucleotides.
General Readings General / background references:Seibert AF et al. Reversal of increased microvascular permeability associated with ischemia-reperfusion: role of cAMP. J Appl Physiol 72:389-95 (1992). PubMed PMID: 1311292
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
Whole antisera
Buffer System:
0.01% Sodium Azide
Purity:
Whole antisera
State:
Serum
Specificity
Specificity:
This reacts with cyclic AMP and to lesser degrees with other 5'

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