AM33041PU-N Carcinoma-associated antigen antibody

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0.1 mg / €320.00
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Mouse anti Human Carcinoma-associated antigen 175F4

AM33041PU-N

Product Description for Carcinoma-associated antigen

Mouse anti Human Carcinoma-associated antigen 175F4.
Presentation: Purified
Product is tested for Frozen Sections.

Properties for Carcinoma-associated antigen

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu
Applications C
Clonality Monoclonal
Clone 175F4
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
EDTA treated human mammary carcinoma cell line (ZR-75-1).
Application Immunohistochemistry on Frozen Sections.
Background The chance of cure and choice of therapy for squamous carcinomas of the head and neck depend largely on the extent of disease, as assessed clinically by inspection,palpation and radiography. Since treatment failures are in part due to clinically undetected metastasis at the time of treatment, there is a need for more specific methods of tumor detection. Attempts to develop antibodies recognizing tumour-associated antigens have, in the case of carcinomas, resulted in the isolation of a large number of antibodies reactive with high-molecular-weight glycoproteins.
Concentration 1.0 mg/ml
General Readings
  1. Balm AJ, Hageman PC, Mulder CL, Hilkens J. Carcinoma-associated monoclonal antibodies in head and neck carcinoma. Immunohistochemistry and biodistribution of monoclonal antibodies 175F4 and 175F11. Eur Arch Otorhinolaryngol. 1992;249(5):237-42. PubMed PMID: 1524802.
  2. Joyce Taylor-Papadimitriou. Report On The First International Workshop On Carcinoma-Associated Mucins. Int. J. Cancer: 49, 1-5 (1991).
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS
Preservatives:
0.09% Sodium Azide
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
175F4, which, originally, has been raised against the human mammary carcinoma cell line (ZR-75-1), react with a carcinoma-associated antigen in both adenocarcinomas and squamous cell carcinomas of different origins. 
Immunohistochemically, the mAbs exhibited reactivity with 42 out of 43 squamous cell carcinomas of the head and neck. Normal squamous epithelia are also reactive with the antibodies in the basal and suprabasal cell layer.

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