CARD12 - NB100-94271 | acris-antibodies.com

Product Description for CARD12

Rabbit anti Human CARD12.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Immunogen	Immunogen: Rabbit anti-Ipaf polyclonal antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf (Genbank accession NP_067032).
Application	Western Blot, This polyclonal antibody can be used for the detection of Ipaf by Western blot at 0.5 to 2 ug/ml. Human peripheral blood leukocyte (PBL) cell lysate can be used as positive control and a 110 kDa band can be detected. Anti-Ipaf is human specific., Western Blot 0.5-2 ug/ml,
Background	Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kappaB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family (1). Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner (2,3). Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.
Storage	Store at 4C. Do not freeze.
Format	Purification: IgG purified Buffer System: 0.02% Sodium Azide Purity: IgG purified State: Purified
Specificity	Specificity: Ipaf Species: Human

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