discontinued

GTX28963 Cardiotin antibody

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0.1 mg / €410.00

Quick Overview

Mouse anti Human Cardiotin SR-2

GTX28963

Product Description for Cardiotin

Mouse anti Human Cardiotin SR-2.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Dot blot, Western blot / Immunoblot, Paraffin Sections.

Properties for Cardiotin

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications C, Dot, P, WB
Clonality Monoclonal
Clone SR-2
Host Mouse
Isotype IgM
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
100 kDa cardiotin subunit.
Application Dot, IHC-Fr, IHC-P, WB
Background Cardiotin is a recently discovered, high molecular weight protein complex (300 kDa) located in the mitochondrial membrane. The cardiotin structure exists of subunits of 60 kDa and 100 kDa. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to human skeletal muscle a-actinin, suggesting that the tetrameric configuration of the cardiotin protein structure is a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. During cardiac contractile dysfunction, the cardiotin distribution is affected in pathological cardiomyocytes i.e. chronic ischemic myocardium. This monoclonal antibody can be used in immunohistochemistry for the detection of a disturbed mitochondrial activity in cardiomyocytes i.e. during chronic ischemia or chronic atrial fibrillation.
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Affinity purified with antigen.
Buffer System:
Phosphate-buffered saline, pH 7.2, containing 0.1% sodium azide
Purity:
Affinity purified with antigen.
State:
Liquid
Aff - Purified
Specificity
Specificity:
Cross-reacts with Human and Pig. Not yet tested in other species.

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