GTX80847 Cardiotin antibody

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0.1 mg / €520.00

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Mouse anti Canine, Hamster, Human, Mouse, Rat Cardiotin R2G


Product Description for Cardiotin

Mouse anti Canine, Hamster, Human, Mouse, Rat Cardiotin R2G.
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Cardiotin

Product Category Primary Antibodies
Quantity 0.1 mg
Reactivity Can, Hst, Hu, Ms, Rt
Applications C, ICC/IF, WB
Clonality Monoclonal
Clone R2G
Host Mouse
Isotype IgM
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Total protein extract of chicken gizzard.
Application IF, IHC, WB
Background Cardiotin is a recently discovered, high molecular weight protein complex (~300 kDa) located in the longitudinal SR of cardiomyocytes. The cardiotin complex exists as 60 kDa and 100 kDa subunits. Both subunits contain the same amino-terminal 14 amino-acid sequence, and show high homology to human skeletal muscle alpha-actin. The tetrameric configuration of the cardiotin protein complex suggests that it exists as a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. Immunofluorescence studies colocalize cardiotin with SERCA 2a ATPase in the longitudinal sarcoplasmic reticulum (SR), although cardiotin is not expressed in junctional SR with SERCA 2. During cardiac contractile dysfunction, markedly decreased sarcoplasmic reticulum activity is detected. The cardiotin distribution is affected in pathological cardiomyocytes (i.e. chronic ischemic myocardium).
Storage -20
100 ug of epitope affinity purified antibody (1 mg/ml) in 0.09% sodium azide.
Canine, Hamster, Human, Mouse, Rat.

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