discontinued

NB100-94189 Caspase 10 antibody

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0.1 mg / €410.00

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Rabbit anti Human, Mouse, Rat Caspase 10

Product Description for Caspase 10

Rabbit anti Human, Mouse, Rat Caspase 10.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Caspase 10

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-caspase-10 polyclonal antibody was raised against a peptide corresponding to amino acids 505 to 521 of human FLICE21.
Add. information Research Areas: Cancer
Application Western Blot, This polyclonal antibody can be used for detection of caspase-10 by Western blot at 1:500 to 1:1000 dilution. HeLa whole cell lysate can be used as positive control and a 59 kDa band can be detected. This antibody only recognizes FLICE2 form of caspase-10. It is human, mouse and rat reactive., Western Blot 1:500-1:1000,
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch41,2 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis1. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death3. Caspase-10 is expressed in many tissues and cell lines1,2.
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
0.02% Sodium Azide
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Casp-10 / FLICE2
Species:
Human, Mouse, Rat

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