discontinued

NB100-94281 Caspase 12 antibody

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Rabbit anti Human, Mouse, Rat Caspase 12

Product Description for Caspase 12

Rabbit anti Human, Mouse, Rat Caspase 12.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Caspase 12

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-caspase-12 (lrg) polyclonal antibody was raised against a synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12 (Genbank accession CAA73532).
Application Western Blot, This polyclonal antibody can be used for the detection of both the propeptide and cleaved forms of caspase-12 by Western blot at 0.5 to 2 ug/ml. Human heart cell lysate can be used as positive control. Anti-caspase-12 (lrg) is human, mouse, and rat reactive., Western Blot 0.5-2 ug/ml,
Background Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).
Storage Store at 4C. Do not freeze.
Format
Purification:
IgG purified
Buffer System:
0.02% Sodium Azide
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Casp-12
Species:
Human, Mouse, Rat

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