TA306197 Caspase-5 (N-term) antibody

Rabbit Polyclonal Caspase-5 Antibody

See related secondary antibodies

Search for all "Caspase-5"

0.1 mg / €371.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human Caspase-5

Product Description for Caspase-5

Rabbit anti Human Caspase-5.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Caspase-5

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P51878
Immunogen:
Human Casp-5 / ICH-3 / ICE rel III (N-Terminus) Peptide (AP30199CP-N)
GeneID:
838
Property N-term
Add. information Blocking peptide available: blocking peptide (AP30199CP-N)
Application ELISA.
Western Blot: Casp-5 antibody can be used for the detection of Caspase-5 at 1 μg/ml. Depending on cell lines or tissues used, other cleavage products may be observed.
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma (5).
General Readings
  1. Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell. 2004 May 28;117(5):561-74. PubMed PMID: 15163405.
  2. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science. 1995 Mar 31;267(5206):2000-3. PubMed PMID: 7535475.
  3. Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.
  4. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002 Aug;10(2):417-26. PubMed PMID: 12191486.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
Caspase-5 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-5.
Species:
Human.

Accessory Products

Proteins and/or Positive Controls

Proteins for Caspase-5 (4 products)

Catalog No. Species Pres. Purity   Source  

Caspase-5 (full length, N-term HIS tag, transcript variant a)

Caspase-5 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Caspase-5

Caspase-5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Caspase-5

Caspase-5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Caspase-5

Caspase-5 Human
  Abnova Taiwan Corp.

Positive controls for Caspase-5 (3 products)

Catalog No. Species Pres. Purity   Source  

CASP5 overexpression lysate

CASP5 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

CASP5 overexpression lysate

CASP5 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

Caspase 5 Lysate

Western Blot: Caspase 5 Lysate [NBL1-08714] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for CASP5.
  Novus Biologicals Inc.
  • LinkedIn