discontinued

AP55950PU-N Caspase 6 (C-term) antibody

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0.1 mg / €450.00

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Rabbit anti Bovine, Chimpanzee, Feline, Human, Rat Caspase 6

AP55950PU-N

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  • AP55950PU-N

Product Description for Caspase 6

Rabbit anti Bovine, Chimpanzee, Feline, Human, Rat Caspase 6.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Caspase 6

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Apoptotic protease Mch-2, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, caspase 6
Presentation Aff - Purified
Reactivity Bov, Chimp, Fe, Hu, Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q6AZ23
Immunogen:
KLH-conjugated linear peptide corresponding to the C-terminus of the large subunit of rat Caspase 6.
GeneID:
103689977
Property C-term
Application Immunohistochemistry: 1:600 dilution from a previous lot detected Caspase 6 in colorectal carcinoma tissue.
Western Blot: 0.5 µg/mL of this antibody detected Caspase 6 in 10 µg of rat kidney tissue lysate..
Background Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase 6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two subunits, an 18 kDa and a 10 kDa subunit that dimerize to form the active enzyme (3). Caspase 6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).
Concentration lot-specific
Storage Store undiluted at 2-8°C.
Shelf life: One year from despatch.
Format
Purification:
Affinity Chromatography
Buffer System:
0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
The antibody recognizes the large subunit of active Caspase 6.
Demonstrated to react with Human and Rat. Predicted to react with Bovine, Feline, and Chimpanzee based on 100% sequence homology.

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