TA328777 CATSPER4 antibody

Rabbit Polyclonal Anti-CatSper4 (extracellular)

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Search for all "CATSPER4"

0.2 ml / €585.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Mouse, Rat CATSPER4

Product Description for CATSPER4

Rabbit anti Mouse, Rat CATSPER4.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for CATSPER4

Product Category Primary Antibodies
Target Category
Quantity 0.2 ml
Synonyms Cation channel sperm-associated protein 4
Presentation Purified
Reactivity Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
Peptide (C)NSYLGQKHYELFSTID, corresponding to amino acid residues 90-105 of mouse CatSper4. 1st extracellular loop.
Application WB: 1:200-1:2000
Background During mammalian fertilization, Ca2+ sigling plays a central role in sperm capacitation and motility to the fusion between sperm and egg. Several Ca2+-permeable ion channel proteins have been characterized in mammalian sperm. However, only the four mammalian CatSper members (CatSpers 1-4) are restrictively expressed in the testis and are clearly shown to be required for male fertility. CatSper channels are med after the first putative cation channel of sperm. CatSper4 contains a single ion transport domain comprised of 6 transmembrane spanning regions, where the fourth transmembrane region resembles a voltage sensor and a pore forming region lies between transmembrane regions 5 and 6. The pore contains the consensus sequence TÃ?DÃ?W indicative of a probable Ca2+ selective channel. The four CatSper proteins are primarily localized to the plasma membrane of the distal portion of the sperm tail and presumably form a heterotetrameric, pH- and voltage-dependent Ca2+-permeable channel . CatSper 4 is highly expressed in testis and expressed at low levels in placenta and lung. Male mice deficient in any of the four CatSper are completely sterile but exhibit no other apparent abnormality. The major phenotypes of the sperm are a lack of hyperactivated motility, a gradual loss of motility after isolation, and an ibility to penetrate zo-intact eggs.
Affinity purified on immobilized antigen.
Buffer System:
Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.

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