TA326517 Cavβ1 Ca2+ Channel antibody

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0.1 mg / €325.00
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Quick Overview

Mouse anti Human, Mouse, Rat Cavβ1 Ca2+ Channel S7-18

Product Description for Cavβ1 Ca2+ Channel

Mouse anti Human, Mouse, Rat Cavβ1 Ca2+ Channel S7-18.
Presentation: Purified
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for Cavβ1 Ca2+ Channel

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu, Ms, Rt
Applications C, IP, WB
Clonality Monoclonal
Clone S7-18
Host Mouse
Isotype IgG2a
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Synthetic peptide amino acids 19-34 of rat Cavβ1
Application Western blot: 1-10 µg/ml (if results are off, try using the
lysate without boiling).
Immunohistochemistry on frozen sections: 0.1-1.0 µg/ml (Perox).
Background Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified (2,3).
Concentration 1.0 mg/ml
General Readings
  1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA.
  2. www.iochannels.org
  3. Leyris J.P., et al. (2009) Faseb J. EPub.
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein G chromatography
Buffer System:
PBS pH7.4, 50% glycerol and 0.09% sodium azide
Liquid Ig fraction
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat
This antibody detects Cavβ1 Ca2+ Channel at ~80, 55 kDa. No cross reactivity observed against Cavβ4.

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