NBP1-21439 CCR2 antibody

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Goat anti Human CCR2

Product Description for CCR2

Goat anti Human CCR2.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for CCR2

Product Category Primary Antibodies
Quantity 0.05 mg
Synonyms anti-C C CKR 2 antibody, anti-C C chemokine receptor type 2 antibody, anti-CC CKR 2 antibody, anti-CC chemokine receptor type 2 antibody, anti-CCCKR2 antibody, anti-CCR 2 antibody, anti-CCR1L antibody, anti-CCR2A antibody, anti-CCR2B antibody, anti-CCR5L antibody, anti-CD192 antibody, anti-CD192 antigen antibody, anti-CKR 2 antibody, anti-CKR2 antibody, anti-CKR2A antibody, anti-CKR2B antibody, anti-CMKBR2 antibody, anti-Chemokine C C motif receptor 2 antibody, anti-Chemokine CC Motif Receptor 2 antibody, anti-MCP 1 R antibody, anti-MCP1 RECEPTOR antibody, anti-MCP1R antibody, anti-Monocyte Chemotactic Protein 1 Receptor antib, anti-Monocyte chemoattractant protein 1 receptor a
Presentation Aff - Purified
Reactivity Hu
Applications E, P, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide C-GEEVTTFFDYDYGAPCHKFDVKQ corresponding to amino acids 17-39 within the N-terminal region of human CD192.
Add. information Research Areas: Immunology
Application ELISA, Immunohistochemistry-Paraffin, Western Blot, ELISA, Western Blot, Immunohistochemistry-Paraffin , ELISA 1:60000, Western Blot 1:1000, Immunohistochemistry-Paraffin 1:200
Background CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.
Concentration 1 mg/ml
Storage Store at -20C. Avoid freeze-thaw cycles.
Affinity purified
Buffer System:
0.09% Sodium Azide
Affinity purified
Aff - Purified
NBP1-21439 specifically recognizes an epitope within the N-terminal (NT) region of human CD192, otherwise known as CCR2 (C-C chemokine receptor type 2), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4. Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1.

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