NBP1-21503 CCR5 antibody

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Goat anti Human, Monkey CCR5


Product Description for CCR5

Goat anti Human, Monkey CCR5.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for CCR5

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Anti-AM4 7 antibody, Anti-C C CKR 5 antibody, Anti-C C chemokine receptor type 5 antibody, Anti-CC CKR 5 antibody, Anti-CC Chemokine Receptor Type 5 antibody, Anti-CCCKR 5 antibody, Anti-CCCKR5 antibody, Anti-CCR 5 antibody, Anti-CCR5 antibody, Anti-CCR5 chemokine (C C motif) receptor 5 antibod, Anti-CKR 5 antibody, Anti-CKR5 antibody, Anti-CMKBR 5 antibody, Anti-Chemokine C C motif receptor 5 antibody, Anti-HIV 1 Fusion Coreceptor antibody, Anti-HIV1 fusion coreceptor antibody, anti-CD 195 antibody, anti-CD195 antibody, anti-CD195 antigen antibody, anti-CHEMR13 antibody, anti-CMKBR5 antibody
Presentation Aff - Purified
Reactivity Hu, Mky
Applications C, E, P, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide YQVSSPIYDINYYTSEPCQKINVKQIAA corresponding to amino acids 3-30 within the N-terminal region of human CD195.
Add. information Research Areas: Immunology
Application ELISA, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot, ELISA, Western Blot, Immunohistochemistry-Paraffin or Frozen This product may require antigen retrieval using EDTA buffer. , ELISA 1:50000, Western Blot 1:1000, Immunohistochemistry-Paraffin 1:300, Immunohistochemistry-Frozen
Background The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Concentration 1 mg/ml
Storage Store at -20C. Avoid freeze-thaw cycles.
Affinity purified
Buffer System:
0.09% Sodium Azide
Affinity purified
Aff - Purified
NBP1-21503 specifically recognizes an epitope within the N-terminal (NT) region of human CD195, otherwise known as CCR5 (C-C chemokine receptor type 5), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, preferentially expressed by a subset of memory Th1 (type 1 helper T) cells. CD195 acts as a high-affinity receptor for several chemotactic chemokines, including MIP-1 alpha (macrophage inflammatory protein 1 alpha), MIP-1 beta, and RANTES (regulated on activation normal T expressed and secreted protein). CD195 is also a major co-receptor for HIV-1 infection, with variations in the CD195 gene, influencing the rate of progression into AIDS. NBP1-21503 is reported as suitable for use in immunocytochemistry on human peripheral blood leucocytes.
Human, Primate

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