AM05883PU-N CD11R3 antibody

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0.25 mg / €570.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Porcine CD11R3 2F4/11


Product Description for CD11R3

Mouse anti Porcine CD11R3 2F4/11.
Presentation: Purified
Product is tested for Frozen Sections, Functional assay, Immunoprecipitation, Western blot / Immunoblot, Flow Cytometry.

Properties for CD11R3

Product Category Primary Antibodies
Quantity 0.25 mg
Presentation Purified
Reactivity Por
Applications C, F, FN, IP, WB
Clonality Monoclonal
Clone 2F4/11
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Porcine alveolar macrophages
Isotype control AM03095PU-N
Application Immunohistochemistry on frozen sections.
Western blot: detects a band of approximately 155 kDa in alveolar macrophage lysates under reducing conditions.
Flow cytometry: 1:25 - 1:50.
Functional assays: Clone 2F4/11 is reported to block phagocytosis of complement-opsonised zymosan particles by polymononuclear granulocytes and alveolar macrophages (1). Removal of sodium azide is recommended prior to use.
Positive control: Porcine spleen.
Concentration 1.0 mg/ml
General Readings
  1. Bullido R, Alonso F, Gómez del Moral M, Ezquerra A, Alvarez B, Ortuño, et al. Monoclonal antibody 2F4/11 recognizes the alpha chain of a porcine beta 2 integrin involved in adhesion and complement mediated phagocytosis. J Immunol Methods. 1996 Sep 9;195(1-2):125-34. PubMed PMID: 8814327.
  2. Domínguez J, Alvarez B, Alonso F, Thacker E, Haverson K, McCullough K, et al. Workshop studies on monoclonal antibodies in the myeloid panel with CD11 specificity. Vet Immunol Immunopathol. 2001 Jul 20;80(1-2):111-9. PubMed PMID: 11445222.
  3. Sánchez-Torres C, Gómez-Puertas P, Gómez-del-Moral M, Alonso F, Escribano JM, Ezquerra A, et al. Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection. Arch Virol. 2003 Dec;148(12):2307-23. Epub 2003 Sep 16. PubMed PMID: 14648288.
  4. Van de Walle GR, Favoreel HW, Nauwynck HJ, Mettenleiter TC, Pensaert MB. Transmission of pseudorabies virus from immune-masked blood monocytes to endothelial cells. J Gen Virol. 2003 Mar;84(Pt 3):629-37. PubMed PMID: 12604815.
  5. Alvarez B, Doménech N, Alonso F, Sánchez C, Gómez del Moral M, Ezquerra A, et al. Molecular and functional characterization of porcine LFA-1 using monoclonal antibodies to CD11a and CD18. Xenotransplantation. 2000 Nov;7(4):258-66. PubMed PMID: 11081760.
Storage Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf life: one year from despatch.
Affinity chromatography on Protein G
Buffer System:
Phosphate buffered saline pH 7.4 0.09% Sodium Azide
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Liquid Ig fraction
This antibody recognises porcine CD11R3, a 155kD cell surface marker which is a member of the alpha integrin family. CD11R3 has a similar expression pattern to the human CD11b marker, being expressed on granulocytes, monocytes and alveolar macrophages, but not on lymphocytes, eythrocytes or platelets.

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