SM2036PT CD158 / KIR2D antibody

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25 µg / €180.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD158 / KIR2D NKVFS1

Product Description for CD158 / KIR2D

Mouse anti Human CD158 / KIR2D NKVFS1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot, Flow Cytometry.

Properties for CD158 / KIR2D

Product Category Primary Antibodies
Target Category
Quantity 25 µg
Synonyms CD158a, CD158b, CD158i, KI2DL1, KILLER CELL Immunoglobin-Like Receptors, KIR2DL3, KIR2DS4
Presentation Aff - Purified
Reactivity Hu
Applications E, F, IP, WB
Clonality Monoclonal
Clone NKVFS1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Flow Cytometry: 1/50 - 1/100; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
ELISA.
Immunoprecipitation.
Western Blot.
Background KIR2D family members are cell surface glycoproteins with two Ig domains, which are expressed on natural killer cells and some T cells.
Concentration 1.0 mg/ml
General Readings
  1. Spaggiari GM, Contini P, Carosio R, Arvigo M, Ghio M, Oddone D, et al. Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood. 2002 Mar 1;99(5):1706-14. PubMed PMID: 11861287.
  2. Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, et al. Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood. 2002 Dec 1;100(12):4098-107. Epub 2002 Jul 18. PubMed PMID: 12393468.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography on Protein G
Buffer System:
PBS, pH7.4 containing 0.09% Sodium Azide
State:
Liquid purified IgG
Aff - Purified
Specificity
Specificity:
This antibody recognises KIR2D members of the killer cell immunoglobulin (Ig)-like receptor (KIR) family, CD158a, CD158b and P50.3 (CD158I). Clone NKVFS1 specifically recognises the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). The clone is reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms. We recommend the use of SM2036A for this purpose.
Species:
Human.
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