AM26776RP-N CD158F / KIR2DL5A antibody

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100 Tests / €290.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD158F / KIR2DL5A UP-R1

AM26776RP-N

Product Description for CD158F / KIR2DL5A

Mouse anti Human CD158F / KIR2DL5A UP-R1.
Presentation: PE
Product is tested for Flow Cytometry.

Properties for CD158F / KIR2DL5A

Product Category Primary Antibodies
Target Category
Quantity 100 Tests
Synonyms CD158F1, KIR2DL5, Killer cell immunoglobulin-like receptor 2DL5A
Presentation PE
Reactivity Hu
Applications F
Clonality Monoclonal
Clone UP-R1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8N109
Immunogen:
Human CD158f-Ig fusion protein
GeneID:
57292
Isotype control SM10R (for use in human samples)
Application Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Background CD158f, also known as KIR2DL5, is a polymorphic 60 kDa transmembrane glycoprotein with two Ig-like extracellular domains by which it recognize HLA class I molecules. Its long intracellular domain contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that upon extracellular ligand-mediated phosphorylation serve as docking sites for inhibitory phosphatases, which results in blocking natural cytotoxicity as well as antibody-dependent cytotoxicity of the particular NK cell, and its adhesion toward target cells. Together with other killer inhibitory receptors CD158f is important for immunological tolerance to discriminate between normal and abnormal cells. Besides NK cells it is expressed on a small population of cytotoxic T cells. Expression of CD158f alleles is highly variable in the population.
General Readings
  1. Du Z, Sharma SK, Spellman S, Reed EF, Rajalingam R. KIR2DL5 alleles mark certain combination of activating KIR genes. Genes Immun. 2008 Jul;9(5):470-80. doi: 10.1038/gene.2008.39. Epub 2008 May 29. PubMed PMID: 18509341.
  2. Yusa S, Catina TL, Campbell KS. KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2). J Immunol. 2004 Jun 15;172(12):7385-92. PubMed PMID: 15187115.
  3. Estefanía E, Flores R, Gómez-Lozano N, Aguilar H, López-Botet M, Vilches C. Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. J Immunol. 2007 Apr 1;178(7):4402-10. PubMed PMID: 17371997.
Storage Store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
PE
Buffer System:
Phosphate buffered saline (PBS)
Preservatives:
15 mM sodium azide
Stabilizers:
0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA)
State:
Liquid puriified Ig fraction
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody recognizes CD158f (KIR2DL5), a 60 kDa glycoprotein serving as a HLA class I ligand, and mainly expressed on a subset of NK cells and a small population of T cells. Its expression is highly polymorphic between individuals.

Accessory Products

Proteins and/or Positive Controls

Proteins for CD158F / KIR2DL5A (1 products)

Catalog No. Species Pres. Purity   Source  

CD158F / KIR2DL5A

CD158F / KIR2DL5A Human
  Abnova Taiwan Corp.

Positive controls for CD158F / KIR2DL5A (1 products)

Catalog No. Species Pres. Purity   Source  

KIR2DL5A overexpression lysate

KIR2DL5A overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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