AM08040FC-N CD16/CD32 antibody

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0.5 mg / €340.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rat anti Mouse CD16/CD32 93

Product Description for CD16/CD32

Rat anti Mouse CD16/CD32 93.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for CD16/CD32

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms CD16a, FCG3, FCGR3A, Fc gamma receptor IIB, Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIIIa, Fc-gamma-RIIB, FcR mouse Seroblock, FcRII, FcRIII, FcRIIIa, Fcgr2, IGFR3, IgG Fc receptor II beta, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor II/III, Ly-17, Lymphocyte antigen 17
Presentation FITC
Reactivity Ms
Applications F
Clonality Monoclonal
Clone 93
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Flow Cytometry: < / 3 µg/10e6 cells. (Ref.4,7,8)
Background The lymphocyte Fc-gamma Receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. (Ref.1,2)
The Fc-gamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. (Ref.1) The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. (Ref.4) Besides identifying Fc-gammaR+ cells, monoclonal antibodies to the Fc-gammaII/III receptor have been used to block Fc receptor binding of IgG, Fcmediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc-gamma R for parasitic invasion. (Ref.4-6)
Concentration 0.5 mg/ml
General Readings
  1. Unkeless, J. C., et al. 1995. Semin. Immunol. 7:37.
  2. Warmerdam, P.A., et al. 1992. Immunobiol. 185:175.
  3. Huizinga, T. W., et al. 1989. J. Immunol. 142:2365.
  4. Ho, A. S-Y., et al. 1995. Mol. and Cell. Biol. 15:5043.
  5. John Kearney, personal communication.
  6. Kurlander, R.J., D. M. Ellison and J. Hall. 1984. J. Immunol. 133:855.
  7. Araujo-Jorge, T., et al. 1993. Infection and Immunity 61:4925.
  8. Titus, J. A., et al. 1984. J. Immunol. 133:556.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Fluorescein Isothiocyanate Isomer 1
Buffer System:
PBS containing 0.09% Sodium Azide as preservative.
Liquid purified Ig fraction.
This antibody is specific to Murine CD16/32 (CD16/FcgII and CD32/FcgIII receptors).
It recognizes a conformational epitope formed by Fc-gammaII and Fc-gamma III Receptors.

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