NB100-77763 CD16 antibody

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Mouse anti Human, Monkey CD16 3G8


Product Description for CD16

Mouse anti Human, Monkey CD16 3G8.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for CD16

Product Category Primary Antibodies
Quantity 100 Tests
Presentation FITC
Reactivity Hu, Mky
Applications F
Clonality Monoclonal
Clone 3G8
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Isotype control SM10F (for use in human samples)
Application flow cytometry / FACS analysis
Background CD16 is known as low affinity IgG receptor III (Fc gammaRIII). It is expressed as two distinct (CD16a and CD16b) forms. CD16a (Fc gammaRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (Fc gammaRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. It is over 95% homologous to CD16a in extracellular domain and is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex that functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). The 3G8 antibody blocks neutrophil phagocytosis and stimulates NK cell proliferation.
General Readings
  1. Fleit, H., et al., 1982. PNAS 79: 3275. 2. Stroncek, D., et al., 1991. Blood 77: 1572. 3. Wirthmueller, U., et al., 1992. J. Exp. Med. 175: 1381.
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Immunogen affinity purified
Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus, Marmoset.

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