NB100-78075 CD167a antibody

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Mouse anti Human CD167a 48B3


Product Description for CD167a

Mouse anti Human CD167a 48B3.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Flow Cytometry.

Properties for CD167a

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications F, IP
Clonality Monoclonal
Clone 48B3
Host Mouse
Isotype IgM
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

NIH-3T3 cells transfected with human DDR1 (CD167a)
Application flow cytometry / FACS analysis, immunoprecipitation
Background The 48B3 monclonal antibody recognizes human CD167a also known as discoidin domain receptor, DDR1, neuroepithelial tyrosine kinase, epithelial-specific receptor kinase, tyrosine kinase receptor E (trkE), cell adhesion kinase (CAK), PTK3, and RTK6. CD167a is a membrane type II receptor kinase, containing a factor VIII-like domain. Three isoforms of CD167a have been reported. Predicted molecular weights are: isoform 1, approximately 101.5 kD, isoform 2, approximately 101 kD, and isoform 3 approximately 97 kD. CD167a is expressed on epithelial cells, keratinocytes, leukocytes, monocytes and has been reported to be overexpressed in some breast carcinomas. CD167a expression can be upregulated by p53. CD167a has been reported to interact with a variety of proteins including collagen type II alpha 1, collagen type III alpha 1, collagen type V alpha 2, collagen type XI alpha 1, phospholipase gamma 1, SHC, and the lipid-anchored docking protein FRS2. CD167a can be phosphorylated on Y513. Animal studies suggest that CD167a is involved in arterial wound healing. The 48B3 antibody has been shown to be useful for flow cytometric detection of human CD167a as well as immunoprecipitation.
General Readings
  1. DiMarco, E., et al. 1993. J. Biol. Chem. 268:24290.2. Hou, G., et al. 2001. J. Clin. Invest. 107:727.3. Johnson, J.D., et al. 1993. Proc. Natl. Acad. Sci. USA 90:5677.
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Immunogen affinity purified
Aff - Purified

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