AM26778LE-N CD2 antibody

See related secondary antibodies

Search for all "CD2"

0.1 mg / €210.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD2 TS1/8

AM26778LE-N

Product Description for CD2

Mouse anti Human CD2 TS1/8.
Presentation: PE
Product is tested for Functional assay, Flow Cytometry.

Properties for CD2

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation PE
Reactivity Hu
Applications F, FN
Clonality Monoclonal
Clone TS1/8
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Cytotoxic T lymphocytes
Isotype control SM10R (for use in human samples)
Application Flow cytometry.
Functional application: Blocking.
Background CD2 (also known as LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
Concentration 1.0 mg/ml
General Readings
  1. Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
  2. Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH. Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens. J Immunol. 1987 Jan 15;138(2):358-63. PubMed PMID: 3098838.
  3. Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, et al. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7489-93. PubMed PMID: 6984191. (Free PMC Article available)
  4. Zhang B, Dai M, Li QJ, Zhuang Y. Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. PLoS Genet. 2013 Oct;9(10):e1003887. doi: 10.1371/journal.pgen.1003887. Epub 2013 Oct 31. PubMed PMID: 24204301. (Free PMC Article available, 4 images available)
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Label:
PE
Purification:
Protein-A affinity chromatography
Buffer System:
Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized
Endotoxin level:
Less than 0.01 EU/μg of the protein, as determined by the LAL test
State:
Liquid Ig fraction
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody recognizes CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.

Accessory Products

  • LinkedIn