discontinued

NBP1-22584 CD23 (MHM6) antibody

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0.5 ml / €400.00

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Mouse anti Human CD23 (MHM6) MHM6

NBP1-22584

Product Description for CD23 (MHM6)

Mouse anti Human CD23 (MHM6) MHM6.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for CD23 (MHM6)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-Blast 2 antibody, anti-Blast2 antibody, anti-C type lectin domain family 4 member J antibo, anti-CD 23 antibody, anti-CD 23A antibody, anti-CD23 Antigen antibody, anti-CD23A antibody, anti-CLEC 4J antibody, anti-CLEC4J antibody, anti-FC Receptor IgE Low Affinity II Alpha Polypep, anti-FCE 2 antibody, anti-FCE2 antibody, anti-FCER 2 antibody, anti-FCER2 antibody, anti-FCER2A antibody, anti-Fc epsilon RII antibody, anti-Fc fragment of IgE low affinity II receptor f, anti-IGEBF antibody, anti-IgE Binding Factor antibody, anti-IgE Receptor Lymphocyte antibody, anti-Immunoglobulin E binding factor antibody, anti-Low Affinity Immunoglobulin Epsilon FC Recept, anti-Low affinity immunoglobulin epsilon Fc recept, anti-Ly42 antibody, anti-Lymphocyte IgE receptor antibody
Presentation Supernatant
Reactivity Hu
Applications P
Clonality Monoclonal
Clone MHM6
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
EBV-transformed B lymphoblastoid cells.
Add. information Research Areas: Immunology
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:75
Background The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a
Storage Store at 4C. Do not freeze.
Format
Purification:
Tissue culture supernatant
Buffer System:
Sodium Azide
Purity:
Tissue culture supernatant
State:
Supernatant
Specificity
Specificity:
This reacts with a glycoprotein of MW 45 kD, present on the surface of peripheral blood and tonsil B cells. It stains the mantle zone lymphocytes and a fraction of dendritic reticulum cells. This stains B cells in chronic lymphocytic leukemia.
Species:
Human

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