NB100-63634 CD25 / IL2RA antibody

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Mouse anti Rat CD25 / IL2RA OX-39

Product Description for CD25 / IL2RA

Mouse anti Rat CD25 / IL2RA OX-39.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for CD25 / IL2RA

Product Category Primary Antibodies
Quantity 0.05 mg
Synonyms IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, IL2RA, Interleukin-2 receptor alpha chain, TAC antigen, p55
Presentation FITC
Reactivity Rt
Applications F
Clonality Monoclonal
Clone OX-39
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Stimulated Rat T cells
Isotype control SM20F (for use in rat samples)
Application flow cytometry / FACS analysis
Background The IL2 receptor (IL2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity alpha chain of the IL2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O linked carbohydrates and has a short cytoplasmic tail. CD25 is expressed on activated T cells, B cells, NK cells and monocytes of all mouse strains tested. It is transiently expressed at a low level during B cell development in bone marrow on the CD45R/B220 low TdT- sIg- pre-B II and CD45R/B220low TdT- sIgM+sIgD- immature B cells, but not on the CD45R/B220 low TdT+ sIg- pro-B/pre B I stage nor on CD45R/B220high TdT- sIgM+sIgD+ mature B cells. CD25 is expressed at a higher level during very early T cell development in fetal and adult thymus.
Concentration 0.1 mg/ml
General Readings
  1. Paterson DJ, Jefferies WA, Green JR, Brandon MR, Corthesy P, Puklavec M, et al. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol. 1987 Dec;24(12):1281-90. PubMed PMID: 2828930.
  2. Hayosh NS, Swanborg RH. Autoimmune effector cells. IX. Inhibition of adoptive transfer of autoimmune encephalomyelitis with a monoclonal antibody specific for interleukin 2 receptors. J Immunol. 1987 Jun 1;138(11):3771-5. PubMed PMID: 3108373.
  3. Tellides G, Dallman MJ, Kupiec-Weglinski JW, Diamantstein T, Morris PJ. Functional blocking of the interleukin-2 receptor (IL-2R) may be important in the efficacy of IL-2R antibody therapy. Transplant Proc. 1987 Oct;19(5):4231-3. PubMed PMID: 3118538.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin
protein G purified
Rat. Not yet tested in other species.

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