SM605 CD25 / IL2RA antibody

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Mouse anti Rabbit CD25 / IL2RA KEI-ALPHA1


Product Description for CD25 / IL2RA

Mouse anti Rabbit CD25 / IL2RA KEI-ALPHA1.
Presentation: Supernatant
Product is tested for Frozen Sections, Immunoprecipitation, Flow Cytometry.

Properties for CD25 / IL2RA

Product Category Primary Antibodies
Quantity 2 ml
Synonyms IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, IL2RA, Interleukin-2 receptor alpha chain, TAC antigen, p55
Presentation Supernatant
Reactivity Rb
Applications C, F, IP
Clonality Monoclonal
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Cell membrane preparation of HTLV-1 transformed rabbit T cell line. Spleen cells of immunised BALB/c mice were fused with cells of the mouse PAI myeloma cell line.
Application Flow Cytometry.
Immunohistochemistry on frozen sections.
Background The Interleukin 2 Receptor alpha and beta chains, together with the common gamma chain, constitute the high affinity IL2 receptor present on activated T and B cells, thymocyte subset, pre B cells and T regulatory cells. Homodimeric alpha chains result in low affinity receptor, while homodimeric beta chains produce a medium affinity receptor. Normally an integral membrane protein, soluble IL2 Receptor alpha has been isolated and determined to result from extracellular proteolysis. Alternately spliced IL2 Receptor alpha mRNAs have been isolated, but the significance of each is presently unknown.
General Readings
  1. Kotani, M. et al. (1993) Generation of monoclonal antibodies to the rabbit IL-2 receptor a chain (CD25) and its distribution in HTLV-1 transformed rabbit T cells. J. Cancer. Res. 84: 770 - 775.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
Containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum and 0.09% Sodium Azide
Liquid Tissue Culture Supernatant
This antibody recognises the CD25 cell surface antigen, the IL-2 receptor a chain. The antibody is reported to inhibit binding of IL-2 to the receptor.

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