SM1847LE CD253 / TRAIL (95-281) antibody

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0.1 mg / €260.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD253 / TRAIL 2E5

Product Description for CD253 / TRAIL

Mouse anti Human CD253 / TRAIL 2E5.
Properties: (95-281)
Presentation: Low Endotoxin
Product is tested for Flow Cytometry, Functional assay.

Properties for CD253 / TRAIL

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms APO2L, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, TNFSF10, Tumor necrosis factor ligand superfamily member 10
Presentation Low Endotoxin
Reactivity Hu
Applications F, FN
Clonality Monoclonal
Clone 2E5
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P50591
Immunogen:
Recombinant soluble fragment (aa 95-281) of human TRAIL
GeneID:
8743
Property 95-281
Isotype control SM10LE (for use in human samples)
Application Functional application: High neutralizing activity for human TRAIL in biological assays.
Flow cytometry: 1-10 μg/ml.
Background Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).
Concentration 1.0 mg/ml
General Readings
  1. Plasilova M, Zivny J, Jelinek J, Neuwirtova R, Cermak J, Necas E, et al. TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia. 2002 Jan;16(1):67-73. PubMed PMID: 11840265.
  2. Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M, et al. Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res. 2005 Jun 1;65(11):4799-808. PubMed PMID: 15930300.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Protein A (> 95% pure by SDS-PAGE)
Buffer System:
Buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized
Endotoxin level:
Less than 0.01 EU/μg of the protein, as determined by the LAL test
State:
Liquid Ig fraction
Low Endotoxin
Species Reactivity
Species reactivity (tested):
Human. Does not work in Mouse.
Specificity
Specificity:
This antibody reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.

Accessory Products

Proteins and/or Positive Controls

Proteins for CD253 / TRAIL (19 products)

Catalog No. Species Pres. Purity   Source  

CD253 / TRAIL (transcript variant 2)

CD253 / TRAIL Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

CD253 / TRAIL (transcript variant 1)

CD253 / TRAIL Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €139.00
  OriGene Technologies, Inc.

CD253 / TRAIL (transcript variant 1)

CD253 / TRAIL Human > 98 %
Preparation: .
Purity Detail: >98% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €143.00
  OriGene Technologies, Inc.

CD253 / TRAIL (transcript variant 1)

CD253 / TRAIL Human > 98 %
Preparation: .
Purity Detail: >98% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
0.1 mg / €978.00
  OriGene Technologies, Inc.

CD253 / TRAIL

CD253 / TRAIL Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
0.1 mg / €399.00
  OriGene Technologies, Inc.

CD253 / TRAIL (114-281)

CD253 / TRAIL Human Purified ≥ 95 by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

CD253 / TRAIL (114-281)

CD253 / TRAIL Human Purified ≥ 95 by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

CD253 / TRAIL

CD253 / TRAIL Human Purified > 98 % by SDS PAGE and HPLC analysis E. coli
  Acris Antibodies GmbH

CD253 / TRAIL

CD253 / TRAIL Human Purified > 98 % by SDS PAGE and HPLC analysis E. coli
  Acris Antibodies GmbH

CD253 / TRAIL

CD253 / TRAIL Human
  Abnova Taiwan Corp.

CD253 / TRAIL

CD253 / TRAIL Human Human HEK293T cells
  Abnova Taiwan Corp.

CD253 / TRAIL

CD253 / TRAIL Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD253 / TRAIL

CD253 / TRAIL Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD253 / TRAIL

CD253 / TRAIL Human
  Abnova Taiwan Corp.

CD253 / TRAIL

CD253 / TRAIL Human
  Abnova Taiwan Corp.

CD253 / TRAIL

CD253 / TRAIL Human Purified > 97 % E. coli
10 µg / €150.00
  Neuromics Antibodies

CD253 / TRAIL

CD253 / TRAIL Human Purified > 97 % E. coli
50 µg / €260.00
  Neuromics Antibodies

CD253 / TRAIL

SDS-Page: TRAIL Protein [NBC1-18505] - TRAIL, 19.6 kDa (169 aa) with a purity of 95% by SDS - PAGE Protein
  Novus Biologicals Inc.

CD253 / TRAIL

CD253 / TRAIL Human Purified
  Novus Biologicals Inc.

Positive controls for CD253 / TRAIL (2 products)

Catalog No. Species Pres. Purity   Source  

CD253 / TRAIL Lysate(Denatured)

CD253 / TRAIL Lysate(Denatured)
  Abnova Taiwan Corp.

TRAIL Lysate

Western Blot: TRAIL Lysate [NBL1-17161] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for TNFSF10
  Novus Biologicals Inc.
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