AM05614RP-N CD279 / PD1 antibody

See related secondary antibodies

Search for all "CD279 / PD1"

100 Tests / €480.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD279 / PD1 MIH4

AM05614RP-N

Product Description for CD279 / PD1

Mouse anti Human CD279 / PD1 MIH4.
Presentation: PE
Product is tested for Flow Cytometry.

Properties for CD279 / PD1

Product Category Primary Antibodies
Target Category
Quantity 100 Tests
Synonyms PDCD1, Programmed cell death protein 1, Protein PD-1, hPD-1
Presentation PE
Reactivity Hu
Applications F
Clonality Monoclonal
Clone MIH4
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q15116
Immunogen:
Human CD279 - transfected L cells.
GeneID:
5133
Isotype control SM10R (for use in human samples)
Application Flow Cytometry.
Background CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
Caution (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Concentration 0,1 mg/ml
General Readings
  1. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol. 2003 Oct 15;171(8):4156-63. PubMed PMID: 14530338.
  2. Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med. 2006 Oct 2;203(10):2223-7. Epub 2006 Sep 25. PubMed PMID: 17000870. (Free PMC Article available, 2 images available)
  3. Keir, M.E. et al. (2007) PD-1 and its ligands in T-cell immunity. Curr. Opin. Immunol. 19: 309 - 314.
Storage Prior to and following reconstitution store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
R. Phycoerythrin (RPE)
PE
Purification:
Affinity chromatography on Protein G
Buffer System:
Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide (NaN3) and 1% Bovine Serum Albumin
Purity:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
State:
Lyophilised purified IgG
Reconstitution:
Reconstitute with 1.0ml distilled water
Specificity
Specificity:
This antibody detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1).
Species:
Human.
Gene ID 5133
FocusOn and Reviews
FocusOns:

Accessory Products

Proteins and/or Positive Controls

Proteins for CD279 / PD1 (12 products)

Catalog No. Species Pres. Purity   Source  

CD279 / PD1

CD279 / PD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

CD279 / PD1 (C-term DDK/His tag)

CD279 / PD1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

CD279 / PD1 (C-term Fc tag)

CD279 / PD1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

CD279 / PD1

CD279 / PD1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
  OriGene Technologies, Inc.

CD279 / PD1

CD279 / PD1 Human
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human Human HEK293T cells
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human Human HEK293T cells
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human Purified
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human Purified
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

CD279 / PD1

CD279 / PD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for CD279 / PD1 (2 products)

Catalog No. Species Pres. Purity   Source  

PDCD1 293T Cell Transient Overexpression Lysate(Denatured)

PDCD1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

PDCD1 overexpression lysate

PDCD1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
  • LinkedIn