NB100-63650 CD28 antibody

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Hamster anti Mouse CD28 37.51.1

Product Description for CD28

Hamster anti Mouse CD28 37.51.1.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for CD28

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms T-cell-specific surface glycoprotein CD28, TP44
Presentation FITC
Reactivity Ms
Applications F
Clonality Monoclonal
Clone 37.51.1
Host Hamster
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Mouse T-Lymphoma EL-4 cells
Application flow cytometry / FACS analysis
Background Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide MHC complexes, and the second is delivered by accessory or costimulating molecules through their counter receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ and CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells and on interferon gamma treated monocytes. The binding of B7 1/BB 1 molecules to CD28 is involved in T lymphocyte activation and in the initiation and maintenance of chronic inflammation.
Concentration 0.5 mg/ml
General Readings
  1. Kawasaki H, Nakata Y, Suzuki G, Chihara K, Tokuhisa T, Shiozawa S. Increased c-Fos/activator protein-1 confers resistance against anergy induction on antigen-specific T cell. Int Immunol. 1999 Dec;11(12):1873-80. PubMed PMID: 10590252.
  2. Gross, G.A. et al. (1992) Identification and distribution of the co-stimulatory receptor CD28 in the mouse. J. Immunol. 149: 380 - 388.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin
protein G purified
Mouse. Not yet tested in other species.

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