NB100-63682 CD3 antibody

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Mouse anti Human CD3 UCHT1

Product Description for CD3

Mouse anti Human CD3 UCHT1.
Presentation: Biotin
Product is tested for Flow Cytometry.

Properties for CD3

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CD247, CD3 delta chain, CD3 epsilon chain, CD3 gamma chain, CD3 zeta chain, CD3D, CD3E, CD3G, CD3Z, T-cell surface glycoprotein CD3, T3D, T3G, T3Z, TCRZ
Presentation Biotin
Reactivity Hu
Applications F
Clonality Monoclonal
Clone UCHT1
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Human infant thymocytes and lymphocytes from a patient with Sezary Syndrome
Isotype control SM10B (for use in human samples)
Application flow cytometry / FACS analysis
Background T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Concentration 0.1 mg/ml
General Readings
  1. Beverley, P.C.L. and Callard, R.E. (1981) Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti T-cell antibody. Eur. J. Immunol. 11: 329-334.
  2. Clark, E.A. et al. (1983) Evolution of epitopes on human and non-human primate lymphoid cell surface antigens. Immunogenetics 18: 599-615.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
Phosphate buffered saline, 1% Bovine Serum Albumin
protein G purified
Human. Not yet tested in other species.

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