NBP1-22757 CD38 (AT13/5) antibody

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Mouse anti Human CD38 (AT13/5) AT13/5


Product Description for CD38 (AT13/5)

Mouse anti Human CD38 (AT13/5) AT13/5.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for CD38 (AT13/5)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-ADP ribosyl cyclase 1 antibody, anti-ADP ribosyl cyclase antibody, anti-Acute lymphoblastic leukemia cells antigen CD, anti-CADPr hydrolase 1 antibody, anti-CD 38 antibody, anti-CD38 antigen antibody, anti-CD38 molecule antibody, anti-Cyclic ADP ribose hydrolase 1 antibody, anti-Cyclic ADP ribose hydrolase antibody, anti-Ecto nicotinamide adenine dinucleotide glycoh, anti-I19 (mouse) antibody, anti-Lymphocyte differentiation antigen CD38 antib, anti-NIMR5 antigen (mouse) antibody, anti-T10 antibody, anti-p45 antibody
Presentation Supernatant
Reactivity Hu
Applications P
Clonality Monoclonal
Clone AT13/5
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

BALB/C mice were immunized with NAMALWA Burkitt
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:100
Background CD38 (T10) is a single chain 42 to 46 kDa type II integral transmembrane glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is expressed by murine, but not human, hematopoietic progenitors. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor. In mice, CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and is not expressed by mature plasma cells. Murine CD38 is also expressed by all Mac1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone marrow derived macrophages. This pattern of expression contrasts strikingly with that seen in the human. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of lymphomas and leukemias, inhibition of B lymphopoiesis, detection of plasma cells, protection of B cells from apoptosis, and as a marker for activated B and T cell proliferation.
Storage Store at 4C. Do not freeze.
Tissue culture supernatant
Buffer System:
Sodium Azide
Tissue culture supernatant
This reacts with a 45 kD type II integral membrane glycoprotein. CD38 is expressed on B cell, thymocytes, granulocytes, T cells, and activated T cells. This reacts with 40-80% of peripheral blood lymphocytes, monocytes, and granulocytes.

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