SM005LE CD4 antibody

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0.5 mg / €540.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rat anti Mouse CD4 YTS191.1

Product Description for CD4

Rat anti Mouse CD4 YTS191.1.
Presentation: Low Endotoxin
Product is tested for Frozen Sections, Functional assay, Flow Cytometry.

Properties for CD4

Product Category Primary Antibodies
Target Category
Quantity 0.5 mg
Synonyms T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
Presentation Low Endotoxin
Reactivity Ms
Applications C, F, FN
Clonality Monoclonal
Clone YTS191.1
Host Rat
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P06332
GeneID:
12504
Add. information Endotoxin Level: less than 0.01 EU/µg
Application Flow Cytometry: Use 10µl of 1/100-1/200 diluted antibody to label 10e6 cells in 100 µl.
Immunohistochemistry on Frozen Sections.
Functional asssays.
Background CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45 % of peripheral blood lymphocytes. It is also present on 80 % of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV.
Concentration 1.0 mg/ml
General Readings
  1. Cobbold SP, Martin G, Waldmann H. The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies. Eur J Immunol. 1990 Dec;20(12):2747-55. PubMed PMID: 1980112.
  2. Bemelman F, Honey K, Adams E, Cobbold S, Waldmann H. Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. J Immunol. 1998 Mar 15;160(6):2645-8. PubMed PMID: 9510162.
  3. Higgins LM, McDonald SA, Whittle N, Crockett N, Shields JG, MacDonald TT. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J Immunol. 1999 Jan 1;162(1):486-93. PubMed PMID: 9886424.
Storage Store the antibody at -20°C only.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography on Protein G
Buffer System:
PBS, pH 7.4 without preservatives.
State:
Liquid purified IgG fraction.
Low Endotoxin
Specificity
Specificity:
This antibody recognises the CD4 cell surface antigen, expressed by a subset of T lymphocytes.
This clone exhibits depleting activity when used in vivo.
Species:
Mouse.
Gene ID 12504

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