SM587R CD4 antibody

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100 Tests / €430.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Guinea Pig CD4 CT7

Product Description for CD4

Mouse anti Guinea Pig CD4 CT7.
Presentation: PE
Product is tested for Flow Cytometry.

Properties for CD4

Product Category Primary Antibodies
Quantity 100 Tests
Synonyms T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, T4/Leu-3
Presentation PE
Reactivity GP
Applications F
Clonality Monoclonal
Clone CT7
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Guinea Pig peritoneal T-cells.
Spleen cells from immunised BALB/c mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.
Application Flow Cytometry.
Background CD4 is a single chain transmembraneous glycoprotein (59 kDa) which belongs to the immunoglobulin superfamily. CD4 is present on a subset of T lymphocytes ("helper/inducer" T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.
General Readings
  1. Tan BT, Ekelaar F, Luirink J, Rimmelzwaan G, De Jonge AJ, Scheper RJ. Production of monoclonal antibodies defining guinea pig T-cell surface markers and a strain 13 Ia-like antigen: the value of immunohistological screening. Hybridoma. 1985 Summer;4(2):115-24. PubMed PMID: 3891587.
  2. Baker D, Karcher K, Antoniou AV, Turk JL, Tan BT, Scheper RJ. Changes in lymphocyte subsets after treatment with cyclophosphamide and during the development of contact sensitivity in the guinea pig. Int J Immunopharmacol. 1987;9(2):175-83. PubMed PMID: 2884193.
  3. Liversidge J, Forrester JV. Experimental autoimmune uveitis (EAU): immunophenotypic analysis of inflammatory cells in chorio retinal lesions. Curr Eye Res. 1988 Dec;7(12):1231-41. PubMed PMID: 3229134.
  4. Steerenburg, P.A. et al. (1991) Tumour rejection after transfer of line-10-immunity is mediated by two T-cell populations. Cancer Immun. Immunother. 34: 103 - 110.
  5. Debout C, Griveau AM, Izard J. The Kurloff cell in estrogenized guinea pigs as a CT7+ 8BE6- CT6- MR-1- CT10- IgM- lymphocyte with natural killer activity. Nat Immun Cell Growth Regul. 1991;10(6):327-35. PubMed PMID: 1787838.
  6. Shang, S. et al. (2010) The activity of TMC 207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs. Antimicrob Agents Chemother. 2010 Oct 11. [Epub ahead of print]
  7. Lacy HM, Bowlin AK, Hennings L, Scurlock AM, Nagarajan UM, Rank RG. Essential role for neutrophils in pathogenesis and adaptive immunity in Chlamydia caviae ocular infections. Infect Immun. 2011 May;79(5):1889-97. doi: 10.1128/IAI.01257-10. Epub 2011 Mar 14. PubMed PMID: 21402767. (Free PMC Article available, 6 images available)
  8. Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, et al. A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity. J Biol Chem. 2011 May 13;286(19):16800-6. doi: 10.1074/jbc.M110.217224. Epub 2011 Mar 25. PubMed PMID: 21454504. (Free PMC Article available, 5 images available)
  9. Jeevan A, Yoshimura T, Lee KE, McMurray DN. Differential expression of gamma interferon mRNA induced by attenuated and virulent Mycobacterium tuberculosis in guinea pig cells after Mycobacterium bovis BCG vaccination. Infect Immun. 2003 Jan;71(1):354-64. PubMed PMID: 12496185. (Free PMC Article available, 8 images available)
  10. Schleiss MR, Lacayo JC, Belkaid Y, McGregor A, Stroup G, Rayner J, et al. Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2007 Mar 15;195(6):789-98. Epub 2007 Feb 6. PubMed PMID: 17299708.
  11. Turner OC, Basaraba RJ, Orme IM. Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis. Infect Immun. 2003 Feb;71(2):864-71. PubMed PMID: 12540568. (Free PMC Article available, 4 images available)
  12. Wang Y, Nagarajan U, Hennings L, Bowlin AK, Rank RG. Local host response to chlamydial urethral infection in male guinea pigs. Infect Immun. 2010 Apr;78(4):1670-81. doi: 10.1128/IAI.01339-09. Epub 2010 Feb 1. PubMed PMID: 20123720. (Free PMC Article available, 10 images available)
  13. Mishra NC, Rir-sima-ah J, March T, Weber W, Benson J, Jaramillo R, et al. Sulfur mustard induces immune sensitization in hairless guinea pigs. Int Immunopharmacol. 2010 Feb;10(2):193-9. doi: 10.1016/j.intimp.2009.10.015. Epub 2009 Nov 1. PubMed PMID: 19887117. (Free PMC Article available, 5 images available)
  14. Hiromatsu K, Dascher CC, LeClair KP, Sugita M, Furlong ST, Brenner MB, et al. Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens. J Immunol. 2002 Jul 1;169(1):330-9. PubMed PMID: 12077262.
  15. Dascher CC, Hiromatsu K, Naylor JW, Brauer PP, Brown KA, Storey JR, et al. Conservation of a CD1 multigene family in the guinea pig. J Immunol. 1999 Nov 15;163(10):5478-88. PubMed PMID: 10553074.
  16. Rousseau C, Turner OC, Rush E, Bordat Y, Sirakova TD, Kolattukudy PE, et al. Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs. Infect Immun. 2003 Aug;71(8):4684-90. PubMed PMID: 12874349. (Free PMC Article available, 6 images available)
  17. Kramp JC, McMurray DN, Formichella C, Jeevan A. The in vivo immunomodulatory effect of recombinant tumour necrosis factor-alpha in guinea pigs vaccinated with Mycobacterium bovis bacille Calmette-Guérin. Clin Exp Immunol. 2011 Jul;165(1):110-20. doi: 10.1111/j.1365-2249.2011.04406.x. Epub 2011 May 5. PubMed PMID: 21545584. (Free PMC Article available, 6 images available)
Storage Store the antibody undiluted at 2-8°C for one month.
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
R. Phycoerythrin (RPE)
Affinity chromatography on Protein G
Buffer System:
PBS, pH 7.4 containing 0.09% Sodium Azide and 1% BSA
Lyophilized purified IgG fraction
Restore with 1.0ml distilled water
This antibody recognizes the CD4 antigen present on T Helper/Inducer lymphocytes.
Guinea Pig.

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