AM32330PU-N CD41-CD61 Complex antibody

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1 ml / €350.00
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Quick Overview

Mouse anti Human CD41-CD61 Complex CRC64


Product Description for CD41-CD61 Complex

Mouse anti Human CD41-CD61 Complex CRC64.
Presentation: Purified
Product is tested for Functional assay, Immunocytochemistry/Immunofluorescence.

Properties for CD41-CD61 Complex

Product Category Primary Antibodies
Quantity 1 ml
Synonyms CD41, CD61, GP2B, GP3A, GPIIb, GPIIb-IIIa, GPalpha IIb, ITGA2B, ITGAB, ITGB3, Integrin alpha-IIb, Integrin beta-3, Platelet membrane glycoprotein IIb
Presentation Purified
Reactivity Hu
Applications FN, ICC/IF
Clonality Monoclonal
Clone CRC64
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Indirect Immunofluorescence staining with analysis by Cytofluorometry in Flow Cytometry or Fluorescence Microsopy.
A platelet aggregation is blocked at the concentration of 1-5 μg/μl.
Concentration 0.2 mg/ml (after reconstitution)
General Readings
  1. Khaspekova, et al., 1993, Br. J. Haematol. 85, 332-340.
  2. Byzova, et al., 1994, Bull. Biol. Exp. 10, 402-405 (in Russian, English translation)

Store undiluted at 2-8°C.
Shelf life: one year from despatch.

Ammonium Sulfate + DEAE-cellulose, gradient elution
Buffer System:
0.09% Sodium Azide
Lyophilized purified Ig fraction
Restore with 1 ml sterile water
Species Reactivity
Species reactivity (tested):
This monoclonal (CRC64) antibody recognizes the intact Platelet GPIIb/IIIa Complex (alphaIIb/beta3-Integrin), i.e. it does not bind to dissociated GPIIb or GPIIIa.
The antibody reacts with Human Platelets and megakaryocytes.
Apparent Molecular Weight under reducing conditions: GPIIIa; 110 kD; GPIIb alpha chain; 125 kD, beta chain; 25 kD.
The antibody does not bind to platelets from patients with Glanzmann thrombasthenia and does not recognize the Vitronectin receptor, which contains GPIIIa as a beta subunit (cf. CD61). CRC64 (both intact antibody and F(ab')2 fragments) inhibits platelet aggregation by blocking fibrinogen binding to the glycoprotein IIb-IIIa complex.
This monoclonal antibody is a useful marker for megakaryoblasts and megakaryoblastic leukemias and also useful for Functional Studies.

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