AM32633PU-N CD41-CD61 Complex antibody

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0.5 mg / €440.00
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Quick Overview

Mouse anti Human CD41-CD61 Complex Y8

AM32633PU-N

Product Description for CD41-CD61 Complex

Mouse anti Human CD41-CD61 Complex Y8.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for CD41-CD61 Complex

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms CD41, CD61, GP2B, GP3A, GPIIb, GPIIb-IIIa, GPalpha IIb, ITGA2B, ITGAB, ITGB3, Integrin alpha-IIb, Integrin beta-3, Platelet membrane glycoprotein IIb
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Monoclonal
Clone Y8
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
10e9 Human platelets suspension.The supernatant fluid from positive clones was screened by ELISA coated with washed platelets.
Application This GPIIb/IIIa antibody is Suitable for use in ELISA and Western Blot.
Use of this MAb at a concentration of 10-20 µg/ml (culture supernatants) will allow visualization of NP 40 solubilized human normal platelets.
Under reducing conditions they will bind against the human platelet membrane glycoproteins IIb/IIIa complex, which have a molecular weights of ~130,000 (IIb) and 115,000 (IIIa).
The titer of purified ascites was determined by ELISA coated with 100 µl of 1x108 washed platelets.
Background The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.
Storage

Store (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity Chromatography on Protein G
Buffer System:
0.01M PBS, pH 7.2 without preservatives
State:
Lyophilized purified IgG fraction
Aff - Purified
Reconstitution:
Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
Human platelet membrane glycoproteins IIb/IIIa (GP IIb/IIIa).

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