AM32331PU-N CD41 / ITGA2B antibody

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1 ml / €350.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD41 / ITGA2B VM16a

AM32331PU-N

Product Description for CD41 / ITGA2B

Mouse anti Human CD41 / ITGA2B VM16a.
Presentation: Purified
Product is tested for Functional assay, Immunocytochemistry/Immunofluorescence.

Properties for CD41 / ITGA2B

Product Category Primary Antibodies
Quantity 1 ml
Synonyms GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb
Presentation Purified
Reactivity Hu
Applications FN, ICC/IF
Clonality Monoclonal
Clone VM16a
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Flow Cytometry.
Functional Assay.
Immunofluorescence. 
General Readings
  1. Vinogradov, D., et al., 1991, Biokhymiya (Biochemistry) 56, 787-797 (in Russian, English translation).
  2. Berndt, P., et al., 1993, Platelets 4, 190-196.
Storage

Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.

Format
Purification:
Ammonium sulfate + DEAE-cellulose, gradient elution
Buffer System:
PBS
Preservatives:
0,09% sodium azide
State:
Lyophilized purified Ig fraction
Purified
Reconstitution:
Reconstitute with 1 ml sterile water.
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:

This antibody recognizes the intact platelet GPIIb/IIIa complex (alphaIIb/beta3), i.e. it does not bind to dissociated GPIIb or GPIIIa. The antibody reacts with human platelets and megakaryocytes. Apparent molecular weight under reducing conditions: GPIIIa; 110 kD; GPIIb alpha chain; 125 kD, beta chain; 25 kD. The antibody does not bind to platelets from patients with Glanzmann thrombasthenia and does not recognize the vitronectin receptor, which contains GPIIIa as a beta subunit (cf. CD61). VM16a inhibits platelet Fc-receptor dependent reactions due to the proposed topographical association of the platelet Fc-receptor and the glycoprotein IIb-IIIa complex.

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