AM32344PU-N CD41 / ITGA2B antibody

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1 ml / €480.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD41 / ITGA2B CLB-48

AM32344PU-N

Product Description for CD41 / ITGA2B

Mouse anti Human CD41 / ITGA2B CLB-48.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for CD41 / ITGA2B

Product Category Primary Antibodies
Quantity 1 ml
Synonyms GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb
Presentation Purified
Reactivity Hu
Applications ICC/IF
Clonality Monoclonal
Clone CLB-48
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human platelets.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Add. information Apparent Molecular Weight (under reducing conditions): GPIIIa; 110kD; GPIIb alpha chain; 125 kD, beta chain; 25kD.
Application Immunofluorescence staining with analysis by FACS or Fluorescence Microscopy. 
Useful Marker for megakaryoblasts and megakaryoblastic leukemias.
Background The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.
Concentration 0.1 mg/ml
General Readings
  1. Modderman, P.W., et al., 1988, Thrombosis and Haemostasis 60, 68.
Storage

Store the antibody undiluted at 2-8°C.
Shelf life: One year from despatch.

Format
Purification:
Ammonium Sulphate Precipitation and Ion Exchange Chromatography
Buffer System:
20mM TRIS, 150mM NaCl, pH 8.0
Preservatives:
0.001% Merthiolate
Stabilizers:
10 mg BSA
State:
Liquid purified Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:

The monoclonal antibody recognizes the intact platelet GPIIb/IIIa complex, i.e. it does not bind to dissociated GPIIb or GPIIIa.
The antibody reacts with Human trombocytes and megakaryocytes. The antibody does not bind to platelets from patients with Glanzmann thrombasthenia and does not recognize the Vitronectin Receptor, which contains GPIIa as a beta subunit (cf. CD61).
The monoclonal antibody activates Human thrombocytes and induces thrombocyte aggregation in the absence of trombocyte inhibitors such as EDTA.

Gene ID 3674

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