NB100-65356 CD43 / Leukosialin antibody

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Mouse anti Rabbit CD43 / Leukosialin L11/135


Product Description for CD43 / Leukosialin

Mouse anti Rabbit CD43 / Leukosialin L11/135.
Presentation: Supernatant
Product is tested for Frozen Sections, Immunoprecipitation, Flow Cytometry.

Properties for CD43 / Leukosialin

Product Category Primary Antibodies
Quantity 2 ml
Synonyms CD43, GALGP, Galactoglycoprotein, Leukocyte sialoglycoprotein, Leukosialin, SPN, Sialophorin
Presentation Supernatant
Reactivity Rb
Applications C, F, IP
Clonality Monoclonal
Clone L11/135
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Glycoproteins from the RL-5 T-cell line
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, immunoprecipitation, Immunohistochemistry-Frozen, Immunoprecipitation, Flow cytometry / FACS analysis, Immunohistochemistry-Frozen immunoprecipitation flow cytometry / FACS analysis
Background CD43 is one of the major glycoproteins of thymocytes and T lymphocytes, it plays a role in the physicochemical properties of the T cell surface and in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. The antigen is a counter receptor for SN/Siglec1. During T cell activation CD43 is actively removed from the T cell antigen presenting cell contact site suggesting a negative regulatory role in adaptive immune response. CD43 is expressed by the majority of leucocytes, with the exception of most B cells. However CD43 expression is seen in some cases of B cell lymphocytic lymphoma and centrocytic lymphoma.
Concentration 16.7 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tissue culture supernatant
Buffer System:
0.09% Sodium Azide
Tissue culture supernatant
NB100-65356 recognizes all T cells by flow cytometry; monocytes and macrophages stain weakly. Good staining of T-Cell dependent areas in lymphoid tissue sections is observed. This antibody immunoprecipitates and immunoblots a 120kD protein from RL-5 cells and T lymphocytes. It is believed to recognize the homologue of Human CD43, Leukosialin. Clone L11/135 has been reported as being suitable for use in Western blotting.

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