SM466 CD43 / Leukosialin antibody

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Mouse anti Sheep CD43 / Leukosialin CO.44B8


Product Description for CD43 / Leukosialin

Mouse anti Sheep CD43 / Leukosialin CO.44B8.
Presentation: Supernatant
Product is tested for Agglutination, Functional assay.

Properties for CD43 / Leukosialin

Product Category Primary Antibodies
Quantity 2 ml
Synonyms CD43, GALGP, Galactoglycoprotein, Leukocyte sialoglycoprotein, Leukosialin, SPN, Sialophorin
Presentation Supernatant
Reactivity Sh
Applications AGG, FN
Clonality Monoclonal
Clone CO.44B8
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Sheep leucocytes. Spleen cells from immunised mice were fused the cells of the SP2-0/Ag14 mouse myeloma cell line.
Application Leucocyte Aggregation.
Functional Assays: 1 : 50.
Background CD43 is one of the major glycoproteins of thymocytes and T lymphocytes, it plays a role in the physicochemical properties of the T cell surface and in lectin binding. CD43 presents carbohydrate ligands to selectins. It has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. The antigen is a counter receptor for SN/Siglec1. During T cell activation CD43 is actively removed from the T cell antigen presenting cell contact site suggesting a negative regulatory role in adaptive immune response.
CD43 is expressed by the majority of leucocytes, with the exception of most B cells. However CD43 expression is seen in some cases of B cell lymphocytic lymphoma and centrocytic lymphoma.
General Readings
  1. Brodersen R, Bijlsma F, Gori K, Jensen KT, Chen W, Dominguez J, et al. Analysis of the immunological cross reactivities of 213 well characterized monoclonal antibodies with specificities against various leucocyte surface antigens of human and 11 animal species. Vet Immunol Immunopathol. 1998 Jun 30;64(1):1-13. PubMed PMID: 9656427.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
Containing 0.09% Sodium Azide
Liquid Tissue Culture Supernatant
This anitbody recognises ruminant CD43, a 105kD cell surface antigen expressed by leucocytes.
Sheep, Bovine.

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