SM1126P CD44v7 + CD44v8 antibody

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0.1 mg / €410.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD44v7 + CD44v8 VFF-17

SM1126P

Product Description for CD44v7 + CD44v8

Mouse anti Human CD44v7 + CD44v8 VFF-17.
Presentation: Purified
Product is tested for Frozen Sections, Western blot / Immunoblot, Flow Cytometry, Paraffin Sections.

Properties for CD44v7 + CD44v8

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CD44, CDw44, ECMR-III, Epican, Extracellular matrix receptor-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein I
Presentation Purified
Reactivity Hu
Applications C, F, P, WB
Clonality Monoclonal
Clone VFF-17
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human CD44v7/8.
Isotype control AM03110PU-N, SM12P
Application Western Blot.
Flow Cytometry: Use 10 µl of 1/10-1/100 diluted antibody to label 106 cells in 100 µl.
Immunohistochemistry on Frozen Sections 1/100-1/1000.
Immunohistochemistry on Paraffin Sections: 1/100. Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Concentration 1.0 mg/ml
General Readings
  1. Wibulswas A, Croft D, Bacarese-Hamilton I, McIntyre P, Genot E, Kramer IM. The CD44v7/8 epitope as a target to restrain proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Am J Pathol. 2000 Dec;157(6):2037-44. PubMed PMID: 11106576. (Free PMC Article available, 7 images available)
  2. Alam TN, O'Hare MJ, Laczkó I, Freeman A, Al-Beidh F, Masters JR, et al. Differential expression of CD44 during human prostate epithelial cell differentiation. J Histochem Cytochem. 2004 Aug;52(8):1083-90. PubMed PMID: 15258184.
  3. Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K. Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells. FASEB J. 2006 Feb;20(2):337-9. Epub 2005 Dec 13. PubMed PMID: 16352650.
  4. Rajarajan A, Stokes A, Bloor BK, Ceder R, Desai H, Grafström RC, et al. CD44 expression in oro-pharyngeal carcinoma tissues and cell lines. PLoS One. 2012;7(1):e28776. doi: 10.1371/journal.pone.0028776. Epub 2012 Jan 5. PubMed PMID: 22242150. (Free PMC Article available, 4 images available)
  5. Bauer S, Jendro MC, Wadle A, Kleber S, Stenner F, Dinser R, et al. Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes. Arthritis Res Ther. 2006;8(6):R171. PubMed PMID: 17105646. (Free PMC Article available, 7 images available)
  6. Shirure, V.S. et al. (2014) CD44 variant isoforms expressed by breast cancer cells are functional E--selectin ligands under flow conditions. Am J Physiol Cell Physiol. Oct 22. [Epub ahead of print]
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS
Preservatives:
None
Stabilizers:
None
State:
Liquid purified IgG fraction
Purified
Specificity
Specificity:
This antibody specifically recognizes an epitope encoded by exons v7-v8 on the variant portion of CD44.
Species:
Human.

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