AM08398FC-N CD45 antibody

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50 µg / €430.00

Quick Overview

Mouse anti Guinea Pig CD45 1H-1

Product Description for CD45

Mouse anti Guinea Pig CD45 1H-1.
Presentation: FITC
Product is tested for Paraffin Sections, Flow Cytometry.

Properties for CD45

Product Category Primary Antibodies
Quantity 50 µg
Synonyms CD45R, CD45RA, CD45RB, CD45RO, L-CA, Leukocyte common antigen, PTPRC, T200
Presentation FITC
Reactivity GP
Applications F, P
Clonality Monoclonal
Clone 1H-1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Flow Cytometry: Use 10 µl of neat-1/10 diluted antobody to label 10e6 cells in 100 µl.
Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
General Readings
  1. Hart IJ, Schäfer H, Scheper RJ, Stevenson GT. Subpopulations of guinea-pig T lymphocytes defined by isoforms of the leucocyte common antigen. Immunology. 1992 Nov;77(3):377-84. PubMed PMID: 1362184. (Free PMC Article available)
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This Product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein A Chromatography.
Buffer System:
PBS, pH 8.0 containing 1% BSA as stabilizer and 0.09% Sodium Azide as preservative.
Liquid purified Ig fraction.
Species Reactivity
Species reactivity (tested):
Guinea Pig.
AM08398FC-N recognizes CD45 on all leucocytes.
Immunoprecipitates proteins of M.Wt. 220,000, 210,000, 195,000 and 180,000 from lymph node lymphocytes and proteins of M.Wt 195,000, 180,000 and 170,000 from thymocytes.

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