AM08044RT-N CD45 / LCA antibody

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0.1 mg / €350.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rat anti Mouse CD45 / LCA I3/2.3

AM08044RT-N

Product Description for CD45 / LCA

Rat anti Mouse CD45 / LCA I3/2.3.
Presentation: PE-TXRD
Product is tested for Immunoprecipitation, Flow Cytometry.

Properties for CD45 / LCA

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
Presentation PE-TXRD
Reactivity Ms
Applications F, IP
Clonality Monoclonal
Clone I3/2.3
Host Rat
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P06800
Application Flow Cytometry: < / = 0.2 µg/10e6 cells. (Ref.4,5)
Immunoprecipitation.(Ref.4)
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 while those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Concentration 0.1 mg/ml
General Readings
  1. Berggreen E, Haug SR, Mkonyi LE, Bletsa A. Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers. Eur J Oral Sci. 2009 Feb;117(1):34-42. doi: 10.1111/j.1600-0722.2008.00592.x. PubMed PMID: 19196316.
  2. Anand RJ, Dai S, Rippel C, Leaphart C, Qureshi F, Gribar SC, et al. Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G109-19. Epub 2007 Nov 1. PubMed PMID: 17975131.
  3. Johnson, P, L. Greenbaum, K. Bottomley and I. S. Trowbridge. 1989. J. Exp. Med. 169:1179.
  4. Haidl, I. D., D. H. W. Ng, S. Rothenberger, P. Johnson, and W. A. Jefferies. 1996. Eur. J. Immunol. 25:3370.
  5. Trowbridge, I.S. 1978. J. Exp. Med. 148:313.
  6. Trowbridge, I.S and M.L. Thomas. 1994. Ann. Rev. Immunol. 12:85
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Label:
R-Phycoerythrin-Texas Red
PE-TXRD
Buffer System:
PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
State:
Liquid purified Ig fraction.
Specificity
Specificity:
This antibody recognizes a framework epitope present on all CD45 isoforms. (Ref.3-6)
Species:
Mouse.

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