NB100-65018 CD45 (CD45R) antibody

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Rat anti Canine CD45 YKIX753.22.2


Product Description for CD45

Rat anti Canine CD45 YKIX753.22.2.
Properties: (CD45R)
Presentation: Aff - Purified
Product is tested for Frozen Sections, Flow Cytometry, Immunoprecipitation, Paraffin Sections.

Properties for CD45

Product Category Primary Antibodies
Quantity 0.125 mg
Synonyms CD45R, L-CA, Leukocyte common antigen, PTPRC, T200
Presentation Aff - Purified
Reactivity Can
Applications C, F, IP, P
Clonality Monoclonal
Clone YKIX753.22.2
Host Rat
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Canine thymocytes
Property CD45R
Add. information Research Areas: Neuroscience, Stem Cell Markers
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, immunoprecipitation, Immunohistochemistry-Frozen, Flow cytometry / FACS analysis, Immunoprecipitation and Cytotoxic Assays, flow cytometry / FACS analysis 1:50 - 1:100, immunoprecipitation , Immunohistochemistry-Frozen
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognizing a common epitope on all of the isoforms are termed CD45 whilst those recognizing only individual isoforms are termed CD45RA or CD45RO etc.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
Aff - Purified
This antibody was clustered as a canine CD45R at the first canine Leucocyte Antigen workshop. It precipitates an antigen of 220kD from Con A Blasts (1) and may be against a CD45R isoform. It is expressed on subsets of leucocytes (neutrophils are weak) in canine blood of all out bred mongrels and beagles tested.

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