SM1582 CD45 (CD45RA) antibody

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2 ml / €450.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Canine CD45 CA4.1D3

SM1582

Product Description for CD45

Mouse anti Canine CD45 CA4.1D3.
Properties: (CD45RA)
Presentation: Supernatant
Product is tested for Frozen Sections, Flow Cytometry.

Properties for CD45

Product Category Primary Antibodies
Quantity 2 ml
Synonyms CD45RA, L-CA, Leukocyte common antigen, PTPRC, T200
Presentation Supernatant
Reactivity Can
Applications C, F
Clonality Monoclonal
Clone CA4.1D3
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Property CD45RA
Application Flow Cytometry.
Immunohistochemistry on Frozen Sections.
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
General Readings
  1. Caniatti M, Roccabianca P, Scanziani E, Paltrinieri S, Moore PF. Canine lymphoma: immunocytochemical analysis of fine-needle aspiration biopsy. Vet Pathol. 1996 Mar;33(2):204-12. PubMed PMID: 8801714.
  2. Cobbold S, Metcalfe S. Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 1994 Mar;43(3):137-54. PubMed PMID: 8091414.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
0.09% Sodium Azide
State:
Liquid Tissue Culture Supernatant
Supernatant
Specificity
Specificity:
This antibody recognizes the Canine homologue of CD45RA, clustered at the first Inrternational canine leukocyte Antigen Workshop (Cobbold et al. 1994).
Clone CA4.1D3 identifies a cell surface glycoprotein expressed by B lymphocytes, a subset of T-lymphocytes, monocytes and thymocytes (Moore et al. 1990).
Species:
Canine (Dog).

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