SM2030R CD45 (CD45R) antibody

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100 Tests / €330.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Sheep CD45 20.96


Product Description for CD45

Mouse anti Sheep CD45 20.96.
Properties: (CD45R)
Presentation: PE
Product is tested for Flow Cytometry.

Properties for CD45

Product Category Primary Antibodies
Quantity 100 Tests
Synonyms CD45R, L-CA, Leukocyte common antigen, PTPRC, T200
Presentation PE
Reactivity Sh
Applications F
Clonality Monoclonal
Clone 20.96
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Ovine thymocytes. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS-1 myeloma cell line.
Property CD45R
Application Flow Cytometry: Use 10 µl of neat antibody to label 1 x 106 cells in 100 µl.
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
General Readings
  1. Mackay CR, Maddox JF, Brandon MR. A monoclonal antibody to the p220 component of sheep LCA identifies B cells and a unique lymphocyte subset. Cell Immunol. 1987 Nov;110(1):46-55. PubMed PMID: 2445494.
  2. Lacroux, C. et al. (2011) Prionemia and leuco-platelet associated infectivity in sheep TSE models. J Virol. Dec 7. [Epub ahead of print]
  3. Dutia BM, Ross AJ, Hopkins J. Analysis of the monoclonal antibodies comprising WC6. Vet Immunol Immunopathol. 1993 Nov;39(1-3):193-9. PubMed PMID: 8310645.
  4. Lee CS, Gogolin-Ewens K, Brandon MR. Identification of a unique lymphocyte subpopulation in the sheep uterus. Immunology. 1988 Jan;63(1):157-64. PubMed PMID: 2962930. (Free PMC Article available)
  5. Debes GF, Arnold CN, Young AJ, Krautwald S, Lipp M, Hay JB, et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol. 2005 Sep;6(9):889-94. Epub 2005 Aug 14. PubMed PMID: 16116468. (Free PMC Article available, 5 images available)
  6. Sedgmen BJ, Lofthouse SA, Scheerlinck JP, Meeusen EN. Cellular and molecular characterisation of the ovine rectal mucosal environment. Vet Immunol Immunopathol. 2002 Jul;86(3-4):215-20. PubMed PMID: 12007887.
  7. Olivier M, Foret B, Le Vern Y, Guilloteau LA. Capacities of migrating CD1b+ lymph dendritic cells to present Salmonella antigens to naive T cells. PLoS One. 2012;7(1):e30430. doi: 10.1371/journal.pone.0030430. Epub 2012 Jan 18. PubMed PMID: 22279590. (Free PMC Article available, 5 images available)
  8. Boppana DK, Wikel SK, Raj DG, Manohar MB, Lalitha J. Cellular infiltration at skin lesions and draining lymph nodes of sheep infested with adult Hyalomma anatolicum anatolicum ticks. Parasitology. 2005 Nov;131(Pt 5):657-67. PubMed PMID: 16255824.
  9. Leemans I, Fossum C, Johannisson A, Hooshmand-Rad P. Comparative studies on surface phenotypes of Theileria lestoquardi and T. annulata schizont-infected cells. Parasitol Res. 2001 Sep;87(9):768-77. PubMed PMID: 11570564.
  10. Tanaka Y, Nakamura S, Shibata H, Kishi Y, Ikeda T, Masuda S, et al. Sustained macroscopic engraftment of cynomolgus embryonic stem cells in xenogeneic large animals after in utero transplantation. Stem Cells Dev. 2008 Apr;17(2):367-81. doi: 10.1089/scd.2007.0119. PubMed PMID: 18447651.
Storage Prior to and following reconstitution store the antibody at 2-8°C.
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
R. Phycoerythrin (RPE)
Affinity Chromatography on Protein G
Buffer System:
PBS, pH 7.4
0.09% Sodium Azide
1% BSA, 5% Sucrose
Lyophilized purified IgG fraction from tissue culture supernatant
This antibody recognises the CD45R cell surface antigen.

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